Adeno-associated virus (AAV) vectors are among the most widely used delivery vehicles for in vivo gene therapy as they mediate robust and sustained transgene expression with limited toxicity.However, a significant impediment to the broad clinical success of AAV-based therapies is the widespread presence of pre-existing humoral immunity to AAVs in t
Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments.Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance.Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting
The potential of artificial hideouts, outfitted with magnets or their imitations (control), to attract spinycheek crayfish Orconectes limosus was studied.The experiments were carried out within 1999-2002 in an 80-hectar natural lake.There were three parallel setups, with three LIP BALB experimental treatments (hideouts) each.The presently acquired
Colorectal cancer (CRC) stands apart from other malignancies due to its pronounced association with dietary patterns.Approximately 70% of all CRC cases arise sporadically, and suboptimal dietary and lifestyle choices can override certain predisposing factors, including a family history of the disease.Hitherto, the most compelling evidence linking C